The Flores Lab

News & Views

	Collaboration with APIS Assay Technologies to assess the suitability of TROLL-2 and TROLL-3 as predictive biomarkers of cancer progression and their role as markers of chemotherapy response https://www.clinicalomics.com/topics/molecular-dx-topic/molecular-diagnostics-in-vitro-diagnostics/target-triple-negative-breast-cancer-first-target-of-moffitt-cancer-center-apis-collaboration/
	Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation Vermes, K. Moffitt Cancer Center Sees Breakthrough in Latest Pan-Cancer Analysis. BioSpace. 2020 Oct 20.
	TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes Parrales A. and Iwakuma T. TAp63-miRNA-AURKA Axis as a Therapeutic Target for Cutaneous Squamous Cell Carcinoma. Cancer Research. 2020 June 05. doi: 10.1158/0008-5472.CAN-20-1215
	∆Np63/DGCR8- Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer. Ferrarelli LK. Predictive biomarkers for HDAC inhibitor efficacy. Science Signaling. 2016 Jul 05. doi: 10.1126/scisignal.aah4647.
	IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. McCarthy N. Feed a cold, starve a tumor. Nature Reviews Cancer. 2014 Dec 11. doi: 10.1038/nrc3881. American Association for Cancer Research. Induction of Metabolic Reprogramming Suppresses p53-Null Tumor Growth. Cancer Discovery. 2014 Dec 04. doi: 10.1158/2159-8290.CD-RW2014-248.
	TAp63 is the master transcriptional regulator of lipid and glucose metabolism Burgess DJ. Metabolism: TAp63 tips the energy balance? Nature Reviews Cancer. 2012 Oct 18. doi: 10.1038/nrc3386.
	TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs Leslie M. Brothers in arms against cancer. Science. 2011 Mar 25. doi: 10.1126/science.331.6024.1551. Alderton GK. Tumor suppression: The burning issue of p63. Nature Reviews Cancer. 2010 Nov 24. doi: 10.1038/nrc2978. Valastyan S. and Weinberg RA. Metastasis suppression: The role of Dice(r). Genome Biology. 2010 Nov 30. doi: 10.1186/gb-2010-11-11-141. Faculty of 1000 – rated 8 (Laura Attardi, Ph.D., Associate Professor, Stanford University)
	DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis Sinha S. Breaking into the Brachury world: ΔNp63 joins in. Cell Cycle. 2010 Jul 01. doi: 10.4161/cc.9.13.12238.
	TAp63 prevents premature aging by promoting adult stem cell maintenance Beaurdy VG and Attardi LD. SKP-ing TAp63: Stem Cell Depletion, Senescence and Premature Aging. Cell Stem Cell. 2009 Jul 02. doi: 10.1016/j.stem.2009.06.015.
	p63 and p73 are required for p53-dependent apoptosis in response to DNA damage Urist M. and Prives C. p53 leans on its siblings. Cancer Cell. 2002 May 01. doi: 10.1016/S1535-6108(02)00064-8. Mitchell A. Apoptosis: The p53 mafia. Nature Reviews Cancer. 2002 May 01. doi: 10.1038/nrc804. Faculty of 1000 – rated 6 (William Kaelin, M.D., Professor, Harvard Medical School, Dana Farber Cancer Institute)