Welcome to The Flores Lab
In the post-genomic era, many gene families have been identified. These genes can have overlapping and independent functions. The existence of redundant functions in gene families has made diseases like cancer challenging to treat and cure. The focus of The Flores Laboratory is to understand the intricacy of the p53 family of genes, p53, p63, and p73, in cancer using mouse genetics and biochemical approaches. The goal of our work is to gain a global understanding of the complex functions of this gene family in cancer and to facilitate the design of targeted therapies for cancer patients with alterations in this the p53 family of genes. Projects in the lab use a multi-faceted approach including the analysis of cancer patient samples, mouse models of cancer, genomics, proteomics and metabolomics approaches to gain a complete understanding of the function of the p53 family in cancer.